Serial plates are not reasonable in material saving and stress dispersion. To design orthopedic plates quickly and conveniently, a method to optimize plates through editing semantic parameters based on average bone model was proposed. Firstly, for reasonable distribution of serial plates in number and size, an average bone model with weights was created from the exiting bones. Secondly, a common orthopedic plate with semantic parameters was constructed based on average bone model and it could be conveniently modified and optimized. Finally, the thickness of the plate was optimized through finite element analysis and bisection strategy to meet the stress condition and use the least material. The experimental results show that the volume of the optimized femur clover plate and the Ⅲ type of the plate for distal femur is decreased by 2.7% and 12.2%, and the maximum stress is decreased by 56.9% and 24.4% respectively. Experimental results indicate that the proposed method can save material and disperse the stress of plates to effectively construct and optimize the orthopedic plates.